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Title: | Ex vivo assessment and in vivo validation of non-invasive stent monitoring techniques based on microwave spectrometry |
Author: | Gálvez Montón, Carolina Arauz-Garofalo, Gianluca Rodríguez Leor, Oriol Soler Botija, Carolina García de Valdecasas, Susana Amorós Gerez Britos, Flavio David Bayés Genís, Antoni O'Callaghan, Juan Manuel Macià Bros, Ferran Tejada Palacios, Javier |
Keywords: | Pròtesis de Stent Espectroscòpia de microones Stents (Surgery) Microwave spectroscopy |
Issue Date: | 4-Oct-2018 |
Publisher: | Nature Publishing Group |
Abstract: | Some conditions are well known to be directly associated with stent failure, including in-stent re-occlusion and stent fracture. Currently, identification of these high-risk conditions requires invasive and complex procedures. This study aims to assess microwave spectrometry (MWS) for monitoring stents non-invasively. Preliminary ex vivo data are presented to move to in vivo validation. Fifteen mice were assigned to receive subcutaneous stent implantations (n = 10) or sham operations (n = 5). MWS measurements were carried out at 0, 2, 4, 7, 14, 22, and 29 days of follow-up. Additionally, 5 stented animals were summited to micro-CT analyses at the same time points. At 29 days, 3 animals were included into a stent fracture subgroup and underwent a last MWS and micro-CT analysis. MWS was able to identify stent position and in-stent stenosis over time, also discerning significant differences from baseline measures (P < 0.001). Moreover, MWS identified fractured vs. non-fractured stents in vivo. Taken together, MWS emerges as a non-invasive, non-ionizing alternative for stent monitoring. MWS analysis clearly distinguished between in-stent stenosis and stent fracture phenomena. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-018-33254-9 |
It is part of: | Scientific Reports, 2018, vol. 8, num. 1, p. 14808 |
URI: | http://hdl.handle.net/2445/176726 |
Related resource: | https://doi.org/10.1038/s41598-018-33254-9 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
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