Please use this identifier to cite or link to this item:
https://dipositint.ub.edu/dspace/handle/2445/180075
Title: | New Distance-Based approach for Genome-Wide Association Studies |
Author: | Irigoien, I. Cormand Rifà, Bru Soler Artigas, M. Sánchez Mora, Cristina Ramos-Quiroga, J.A. Arenas Solà, Concepción |
Keywords: | Genoma humà Trastorns per dèficit d'atenció amb hiperactivitat en els adults Human genome Attention deficit disorder with hyperactivity in adults |
Issue Date: | 23-Jun-2021 |
Publisher: | IEEE CS, CI, and EMB Societies & the ACM |
Abstract: | With the raise of genome-wide association studies (GWAS), the analysis of typical GWAS data sets with thousands of potentially predictive single nucleotide-polymorphisms (SNPs) has become crucial in Biomedicine research. Here, we propose a new method to identify SNPs related to disease in case-control studies. The method, based on genetic distances between individuals, takes into account the possible population substructure, and avoids the issues of multiple testing. The method provides two ordered lists of SNPs; one with SNPs which minor alleles can be considered risk alleles for the disease, and another one with SNPs which minor alleles can be considered as protective. These two lists provide a useful tool to help the researcher to decide where to focus attention in a first stage. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1109/TCBB.2021.3092812 |
It is part of: | IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2021, p. 1-12 |
URI: | http://hdl.handle.net/2445/180075 |
Related resource: | https://doi.org/10.1109/TCBB.2021.3092812 |
ISSN: | 1545-5963 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
707176.pdf | 1.16 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.