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Title: | Does knowing the influenza epidèmic threshold has been reached influence the performance of influenza case definitions? |
Author: | Soldevila, Núria Toledo Zavaleta, Diana Isabel Martínez, Ana Godoy i García, Pere Torner Gràcia, Núria Rius, Cristina Jané, Mireia Domínguez García, Àngela |
Keywords: | Grip Epidèmies Infants Febre Tos Diagnòstic Formulació clínica Metges Influenza Epidemics Children Fever Cough Diagnosis Case formulation Physicians |
Issue Date: | 1-Jul-2022 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Background: Disease surveillance using adequate case definitions is very important. The objective of the study was to compare the performance of influenza case definitions and influenza symptoms in the first two epidemic weeks with respect to other epidemic weeks. Methods: We analysed cases of acute respiratory infection detected by the network of sentinel primary care physicians of Catalonia for 10 seasons. We calculated the diagnostic odds ratio (DOR) and 95% confidence intervals (CI) for the first two epidemic weeks and for other epidemic weeks. Results: A total of 4,338 samples were collected in the epidemic weeks, of which 2,446 (56.4%) were positive for influenza. The most predictive case definition for laboratory-confirmed influenza was the WHO case definition for influenza-like illness (ILI) in the first two epidemic weeks (DOR 2.10; 95% CI 1.57-2.81) and in other epidemic weeks (DOR 2.31; 95% CI 1.96-2.72). The most predictive symptom was fever. After knowing that epidemic threshold had been reached, the DOR of the ILI WHO case definition in children aged <5 years and cough and fever in this group increased (190%, 170% and 213%, respectively). Conclusions: During influenza epidemics, differences in the performance of the case definition and the discriminative ability of symptoms were found according to whether it was known that the epidemic threshold had been reached or not. This suggests that sentinel physicians are stricter in selecting samples to send to the laboratory from patients who present symptoms more specific to influenza after rather than before an influenza epidemic has been declared. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0270740 |
It is part of: | PLoS One, 2022, vol. 17, num. 7, p. e0270740 |
URI: | http://hdl.handle.net/2445/190869 |
Related resource: | https://doi.org/10.1371/journal.pone.0270740 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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