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https://dipositint.ub.edu/dspace/handle/2445/197404
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DC Field | Value | Language |
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dc.contributor.author | Bonelli Blasco, Joaquin Daniel | - |
dc.contributor.author | Velasco de Andrés, María | - |
dc.contributor.author | Isidro, Neus | - |
dc.contributor.author | Bayó, Cristina | - |
dc.contributor.author | Chumillas, Sergi | - |
dc.contributor.author | Carrillo-Serradell, Laura | - |
dc.contributor.author | Casadó Llombart, Sergi | - |
dc.contributor.author | Mok, Cheryl | - |
dc.contributor.author | Benítez-Ribas, Daniel | - |
dc.contributor.author | Lozano Soto, Francisco | - |
dc.contributor.author | Rocas, Josep | - |
dc.contributor.author | Marchán Sancho, Vicente | - |
dc.date.accessioned | 2023-04-28T16:28:01Z | - |
dc.date.available | 2023-04-28T16:28:01Z | - |
dc.date.issued | 2022-12-24 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | http://hdl.handle.net/2445/197404 | - |
dc.description.abstract | Encapsulation of water-soluble bioactive compounds for enabling specific accumulation in tumor locations, while avoiding premature clearance and/or degradation in the bloodstream, is one of the main hallmarks in nanomedicine, especially that of NIR fluorescent probes for cancer theragnosis. The herein reported technology furnishes water-dispersible double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG-NCs), using a versatile and highly efficient one-pot and industrially scalable synthetic process based on the use of two different prepolymers to set up the NCs walls. Flow cytometry and confocal microscopy confirmed that both ICG-loaded NCs internalized in monocyte-derived dendritic cells (moDCs). The in vivo analysis of xenograft A375 mouse melanoma model revealed that amphoteric functionalization of NCs' surface promotes the selective accumulation of ICG-NCs in tumor tissues, making them promising agents for a less-invasive theragnosis of cancer. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: | - |
dc.relation.ispartof | Pharmaceutics, 2022, vol. 15, num. 1, p. 58 | - |
dc.relation.uri | https://doi.org/10.3390/pharmaceutics15010058 | - |
dc.rights | cc-by (c) Bonelli Blasco, Joaquin Daniel et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Biocompatibilitat | - |
dc.subject.classification | Tumors | - |
dc.subject.classification | Poliuretans | - |
dc.subject.other | Biocompatibility | - |
dc.subject.other | Tumors | - |
dc.subject.other | Polyurethanes | - |
dc.title | Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 729644 | - |
dc.date.updated | 2023-04-28T16:28:01Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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729644.pdf | 2.39 MB | Adobe PDF | View/Open |
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