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https://dipositint.ub.edu/dspace/handle/2445/200022
Title: | Gut microbiome signatures linked to HIV-1 reservoir size and viremia control |
Author: | Borgognone, Alessandra Noguera Julian, Marc Oriol-Tordera, Bruna Noël-Romas, Laura Ruiz Riol, Marta Guillén, Yolanda Parera, Mariona Casadellà, Maria Duran Castells, Clara Puertas, Maria C. Català Moll, Francesc Leon, Marlon de Knodel, Samantha Birse, Kenzie Manzardo, Christian Miró, Jose M. Clotet, Bonaventura, 1953- Martínez Picado, Javier Moltó, José Mothe, Beatriz Burgener, Adam Brander, Christian Paredes, Roger BCN02 Study Group |
Keywords: | Microbiota intestinal Marcadors bioquímics Terapèutica Vacuna antivariolosa Gastrointestinal microbiome Biochemical markers Therapeutics Smallpox vaccine |
Issue Date: | 11-Apr-2022 |
Publisher: | BioMed Central |
Abstract: | Background: The potential role of the gut microbiome as a predictor of immune-mediated HIV-1 control in the absence of antiretroviral therapy (ART) is still unknown. In the BCN02 clinical trial, which combined the MVA.HIVconsv immunogen with the latency-reversing agent romidepsin in early-ART treated HIV-1 infected individuals, 23% (3/13) of participants showed sustained low-levels of plasma viremia during 32 weeks of a monitored ART pause (MAP). Here, we present a multi-omics analysis to identify compositional and functional gut microbiome patterns associated with HIV-1 control in the BCN02 trial. Results: Viremic controllers during the MAP (controllers) exhibited higher Bacteroidales/Clostridiales ratio and lower microbial gene richness before vaccination and throughout the study intervention when compared to non-controllers. Longitudinal assessment indicated that the gut microbiome of controllers was enriched in pro-inflammatory bacteria and depleted in butyrate-producing bacteria and methanogenic archaea. Functional profiling also showed that metabolic pathways related to fatty acid and lipid biosynthesis were significantly increased in controllers. Fecal metaproteome analyses confirmed that baseline functional differences were mainly driven by Clostridiales. Participants with high baseline Bacteroidales/Clostridiales ratio had increased pre-existing immune activation-related transcripts. The Bacteroidales/Clostridiales ratio as well as host immune-activation signatures inversely correlated with HIV-1 reservoir size. Conclusions: The present proof-of-concept study suggests the Bacteroidales/Clostridiales ratio as a novel gut microbiome signature associated with HIV-1 reservoir size and immune-mediated viral control after ART interruption. Video abstract. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s40168-022-01247-6 |
It is part of: | Microbiome, 2022, vol. 10, num. 1, p. 59 |
URI: | https://hdl.handle.net/2445/200022 |
Related resource: | https://doi.org/10.1186/s40168-022-01247-6 |
ISSN: | 2049-2618 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) |
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