Please use this identifier to cite or link to this item: https://dipositint.ub.edu/dspace/handle/2445/201842
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dc.contributor.authorRovira, Anna-
dc.contributor.authorOrtega-Forte, Enrique-
dc.contributor.authorHally, Cormac-
dc.contributor.authorJorda-Redondo, Mireia-
dc.contributor.authorAbad-Montero, Diego-
dc.contributor.authorVigueras, Gloria-
dc.contributor.authorMartinez, Jesús I.-
dc.contributor.authorBosch Marimon, Manel-
dc.contributor.authorNonell, Santi-
dc.contributor.authorRuiz, José-
dc.contributor.authorMarchán Sancho, Vicente-
dc.date.accessioned2023-09-08T15:51:44Z-
dc.date.available2023-09-08T15:51:44Z-
dc.date.issued2023-06-02-
dc.identifier.issn0022-2623-
dc.identifier.urihttp://hdl.handle.net/2445/201842-
dc.description.abstractPhotodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under hypoxic conditions remain to be developed. Herein, we took the advantageous properties of COUPY fluorophores and cyclometalated Ir(III) complexes to develop novel PDT agents based on Ir(III)-COUPY conjugates with the aim of exploring structure-activity relationships. The structural modifications carried out within the coumarin scaffold had a strong impact on the photophysical properties and cellular uptake of the conjugates. All Ir(III)-COUPY conjugates exhibited high phototoxicity under green light irradiation, which was attributed to the photogeneration of ROS, while remaining non-toxic in the dark. Among them, two hit conjugates showed excellent phototherapeutic indexes in cisplatin-resistant A2780cis cancer cells, both in normoxia and in hypoxia, suggesting that photoactive therapy approaches based on the conjugation of far-red/NIR-emitting COUPY dyes and transition metal complexes could effectively tackle in vitro acquired resistance to cisplatin.-
dc.format.extent19 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1021/acs.jmedchem.3c00189-
dc.relation.ispartofJournal of Medicinal Chemistry, 2023, vol. 66, num. 12, p. 7849-7867-
dc.relation.urihttps://doi.org/10.1021/acs.jmedchem.3c00189-
dc.rightscc-by (c) Rovira, Anna , 2023-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationCompostos aromàtics-
dc.subject.classificationCèl·lules canceroses-
dc.subject.classificationCumarines-
dc.subject.otherAromatic compounds-
dc.subject.otherCancer cells-
dc.subject.otherCoumarins-
dc.titleExploring Structure-Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec738222-
dc.date.updated2023-09-08T15:51:44Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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