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Title: | Malaria parasites do respond to heat |
Author: | Tintó Font, Elisabet Cortés, Alfred |
Keywords: | Plasmodium falciparum Parasitologia mèdica Febre Plasmodium falciparum Medical parasitology Fever |
Issue Date: | 14-Mar-2022 |
Publisher: | Elsevier BV |
Abstract: | The capacity of malaria parasites to respond to changes in their environment at the transcriptional level has been the subject of debate, but recent evidence has unambiguously demonstrated that Plasmodium spp. can produce adaptive transcriptional responses when exposed to some specific types of stress. These include metabolic conditions and febrile temperature. The Plasmodium falciparum protective response to thermal stress is similar to the response in other organisms, but it is regulated by a transcription factor evolutionarily unrelated to the conserved transcription factor that drives the heat shock (HS) response in most eukaryotes. Of the many genes that change expression during HS, only a subset constitutes an authentic response that contributes to parasite survival. © 2022 Elsevier Ltd |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.pt.2022.02.009 |
It is part of: | Trends In Parasitology, 2022, vol. 38, num. 6, p. 435-449 |
URI: | http://hdl.handle.net/2445/202128 |
Related resource: | https://doi.org/10.1016/j.pt.2022.02.009 |
ISSN: | 1471-5007 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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TintoFont_and_Cortes_postprint_wFigs.pdf | 958.93 kB | Adobe PDF | View/Open |
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