Please use this identifier to cite or link to this item: https://dipositint.ub.edu/dspace/handle/2445/207883
Title: Alkaloid Composition and Biological Activities of the Amaryllidaceae Species <i>Ismene amancaes</i> (Ker Gawl.) Herb.
Author: Soto-Vásquez, Marilú Roxana
Rodríguez-Muñoz, Cecilia Anataly
Tallini, Luciana R.
Bastida Armengol, Jaume
Keywords: Alcaloides
Amaril·lidàcies
Alkaloids
Amaryllidaceae
Issue Date: 22-Jun-2022
Publisher: MDPI
Abstract: Natural products have always played a significant role in the search for new drugs. One of the most relevant alkaloid-containing plant groups is the Amaryllidaceae family, a source of exclusive structures with a wide variety of pharmacological activities. The aim of this work was to determine the alkaloid composition and biological potential of an extract from the bulbs of an endemic Peruvian Amaryllidaceae species Ismene amancaes (Ker Gawl.) Herb. The alkaloid profiling was carried out by GC-MS, which revealed the presence of 13 compounds, 2 of them unidentified. The plant extract was found to contain high amounts of lycoramine, a galanthamine-type alkaloid. The extract also presented low inhibitory potential against the enzymes AChE and BuChE, with IC50 values of 14.6 ± 0.6 and 37.6 ± 1.4 μg·mL-1, respectively, and good to moderate inhibitory activity against the protozoan Plasmodium falciparum strain FCR-3 (chloroquine-resistant), with IC50 values of 3.78 ± 0.3 μg·mL-1. This is the first report of the alkaloid profile of a plant of the Ismene genus, which could be an interesting source of bioactive compounds. Keywords: Alzheimer’s disease; Amaryllidaceae; Ismene amancaes; Plasmodium falciparum; alkaloids; malaria.
Note: Reproducció del document publicat a: https://doi.org/10.3390/plants11151906
It is part of: Plants, 2022
URI: https://hdl.handle.net/2445/207883
Related resource: https://doi.org/10.3390/plants11151906
ISSN: 2223-7747
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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