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DC Field | Value | Language |
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dc.contributor.author | Pedraza A | - |
dc.contributor.author | Salas MQ | - |
dc.contributor.author | Rodríguez-Lobato LG | - |
dc.contributor.author | Escribano-Serrat S | - |
dc.contributor.author | Suárez-Lledó M | - |
dc.contributor.author | Martínez-Cebrian N | - |
dc.contributor.author | Solano MT | - |
dc.contributor.author | Arcarons J | - |
dc.contributor.author | Rosinol L | - |
dc.contributor.author | Gutiérrez-García G | - |
dc.contributor.author | Fernández-Avilés F | - |
dc.contributor.author | Moreno-Castaño AB | - |
dc.contributor.author | Molina P | - |
dc.contributor.author | Pino M | - |
dc.contributor.author | Carreras E | - |
dc.contributor.author | Diaz-Ricart M | - |
dc.contributor.author | Rovira M | - |
dc.contributor.author | Palomo M | - |
dc.contributor.author | Martinez C | - |
dc.date.accessioned | 2024-03-25T10:31:06Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | Pedraza A;Salas MQ;Rodríguez-Lobato LG;Escribano-Serrat S;Suárez-Lledó M;Martínez-Cebrian N;Solano MT;Arcarons J;Rosinol L;Gutiérrez-García G;Fernández-Avilés F;Moreno-Castaño AB;Molina P;Pino M;Carreras E;Diaz-Ricart M;Rovira M;Palomo M;Martinez C. Easix Score Correlates With Endothelial Dysfunction Biomarkers and Predicts Risk of Acute Graft-Versus-Host Disease After Allogeneic Transplantation. Transplantation And Cellular Therapy, 2024, 30, 2, 01706-2-NA | - |
dc.identifier.issn | 9379356 | - |
dc.identifier.uri | http://hdl.handle.net/2445/209143 | - |
dc.description.abstract | Plasma biomarkers of endothelial dysfunction have been postulated for the diagnosis and prognosis of acute graft-versus-host disease (aGVHD). However, their use is not validated in clinical practice yet. The endothelial activation and stress index (EASIX), a simple score based on routine laboratory parameters, is considered to be an indirect marker of endothelial damage. High value of EASIX was correlated with worse non-relapse mortality (NRM) and overall survival (OS) and a high risk of sinusoidal obstructive syndrome (SOS) and transplant-associated thrombotic microangiopathy (TA-TMA).This study investigates the predictive value of plasma biomarkers and the EASIX score for the prediction of aGVHD.We assessed VCAM-1, TNFR1, and VWF:Ag plasma levels, and EASIX score before allogeneic hematopoietic stem cell transplantation (allo-HSCT), and on days 0, +3, +7, +14, and +21 in an experimental cohort (n=33). EASIX was transformed to a base-2 logarithm to perform the analysis. For the most relevant biomarkers, we estimate the optimal cut-off values and the discriminatory ability to differentiate patients with high-risk of aGVHD. The conclusions obtained in the experimental cohort were validated in a large cohort of 321 patients at the same institution.Plasma biomarkers and EASIX showed similar post-transplant dynamics consisting of a progressive increase. Multivariate analysis showed an association between high TNFR1 levels and Log-2 EASIX score on day +7 post-transplant with an increased likelihood of developing aGVHD (HR 1, P=0.002; HR 2.31, P=0.013, respectively). Patients with TNFR1 ≥1300 ng/mL (HR 7.19, P=0.006) and Log2-EASIX ≥3 (HR 14.7, P<0.001) at day +7 post-transplant were more likely to develop aGVHD with high predictive accuracy (C-index of 74% and 81%, respectively). In the validation cohort, patients with Log2-EASIX ≥ 3 on day +7 post-transplant presented a significantly higher incidence of grade II-IV aGVHD (HR 1.94, P=0.004) independent of GVHD prophylaxis (HR 0.38, P=0.004), conditioning regimen (HR 0.59, P=0.02) and type of donor (HR 2.38, P=0.014).Differential degree of endothelial damage can be measured using both EASIX score and plasma biomarkers in the early post-transplant period. Patients at risk of developing aGVHD could be easily identified by a high EASIX score. Both indicators of endothelial activation represent a promising approach to predict aGVHD.Published by Elsevier Inc. | ca |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.jtct.2023.11.016 | - |
dc.relation.ispartof | Transplantation And Cellular Therapy, 2024, 30, 2, 01706-2-NA | - |
dc.relation.uri | https://doi.org/10.1016/j.jtct.2023.11.016 | - |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject | Acute Gvhd | ca |
dc.subject | Allogeneic Hematopoietic Stem Cell Transplantation | ca |
dc.subject | Biomarkers | ca |
dc.subject | EASIX | ca |
dc.subject | Endothelial Dysfunction | ca |
dc.subject | Graft-Versus-Host Disease | ca |
dc.title | Easix Score Correlates With Endothelial Dysfunction Biomarkers and Predicts Risk of Acute Graft-Versus-Host Disease After Allogeneic Transplantation | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.date.updated | 2024-03-25T09:39:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | ca |
dc.embargo.lift | 2024-11-23 | - |
dc.date.embargoEndDate | info:eu-repo/date/embargoEnd/2024-11-23 | ca |
dc.identifier.idimarina | 9379356 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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EASIX_Biomark_Paper_final_reviewed.pdf | 661.34 kB | Adobe PDF | View/Open Request a copy |
Document embargat fins el 23-11-2024
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