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Title: | Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk. |
Author: | Estruch Riba, Ramon Martínez-González, Miguel Ángel, 1957- Corella Piquer, Dolores Basora, Josep Ruiz-Gutiérrez, Valentina Covas Planells, María Isabel Fiol Sala, Miguel Gómez Gracia, Enrique López Sabater, María del Carmen Escoda, Rosa Pena, M. A. Díez Espino, Javier Lahoz, Carlos Lapetra, José Sáez, G. Ros Rahola, Emilio |
Keywords: | Malalties cardiovasculars Epidemiologia Fibra alimentària Estudi de casos Cardiovascular diseases Epidemiology Dietary fiber Case studies |
Issue Date: | 2009 |
Publisher: | BMJ Group |
Abstract: | Background: Epidemiological studies and feeding trials with supplements suggest that fibre intake is associated with a reduction in cardiovascular risk. However, the effects of changes in dietary fibre on risk factor levels have not been evaluated in free-living individuals. Thus, we assessed the 3-month effects of changes in dietary fibre intake on cardiovascular risk factors in free-living high-risk subjects. Methods: 772 high-risk subjects (age 69?5 years) were assigned to a low-fat diet or 2 Mediterranean-style diets. All participants received behavioural and nutritional education, including recommendations for increasing the consumption of vegetables, fruits, and legumes. Changes in food and nutrient intake, body weight, blood pressure, lipid profiles, glucose control, and inflammatory markers were evaluated. Results: Most participants increased consumption of vegetable products, but the increase in dietary fibre exhibited wide between-subject variability (6-65 g/day). Body weight, waist circumference, and mean systolic and diastolic blood pressure decreased across quintiles of fibre intake (P <0.005; all). Reductions in fasting glucose and total cholesterol levels, and increments in HDL cholesterol were highest among participants in the upper 20% of fibre intake (P=0.04 and 0.02, respectively). Plasma concentrations of C-reactive protein, but not those of inflammatory cytokines, decreased in parallel with increasing dietary fibre (P=0.04). Significant reductions in LDL cholesterol were observed only among participants with the greatest increases in soluble fibre intake (P=0.04). Conclusions: Increasing dietary fibre intake with natural foods is associated with reductions in classical and novel cardiovascular risk factors in a high risk cohort. |
Note: | Reproducció digital del document publicat a: http://dx.doi.org/10.1136/jech.2008.082214 |
It is part of: | Journal of Epidemiology and Community Health, 2009, vol. 63, núm. 7, p. 582-588 |
URI: | http://hdl.handle.net/2445/22489 |
Related resource: | http://doi.org/10.1136/jech.2008.082214 |
ISSN: | 0143-005X |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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