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DC Field | Value | Language |
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dc.contributor.author | Herrero Rodríguez, Laura | - |
dc.contributor.author | Mera Nanín, Paula | - |
dc.contributor.author | Orellana Gavaldà, Josep Maria | - |
dc.contributor.author | Gurunathan, Chandrashekaran | - |
dc.contributor.author | Malandrino, Maria Ida | - |
dc.contributor.author | Mir Bonnín, Joan Francesc | - |
dc.contributor.author | Makowski, Kamil | - |
dc.contributor.author | Pozo, Macarena | - |
dc.contributor.author | Arasa, Maria del Mar | - |
dc.contributor.author | Ariza Piquer, Xavier | - |
dc.contributor.author | Asins Muñoz, Guillermina | - |
dc.contributor.author | García Gómez, Jordi | - |
dc.contributor.author | García Hegardt, Fausto | - |
dc.contributor.author | Serra i Cucurull, Dolors | - |
dc.date.accessioned | 2013-10-15T12:15:59Z | - |
dc.date.available | 2013-10-15T12:15:59Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://hdl.handle.net/2445/46996 | - |
dc.description | Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988 | cat |
dc.description.abstract | Strategies that enhance fat degradation or reduce caloric food intake could be considered therapeutic interventions to reduce not only obesity, but also its associated disorders. The enzyme carnitine palmitoyltransferase 1 (CPT1) is the critical rate-determining regulator of fatty acid oxidation (FAO) and might play a key role in increasing energy expenditure and controlling food intake. Our group has shown that mice overexpressing CPT1 in liver are protected from weight gain, the development of obesity and insulin resistance. Regarding food intake control, we observed that the pharmacological inhibition of CPT1 in rat hypothalamus decreased food intake and body weight. This suggests that modulation of CPT1 activity and the oxidation of fatty acids in various tissues can be crucial for the potential treatment of obesity and associated pathologies. | cat |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | eng |
dc.publisher | Transworld Research Network | - |
dc.relation.isformatof | Reproducció del capítol del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=164 | - |
dc.relation.ispartof | Recent Advances in Pharmaceutical Sciences III, 2013, Transworld Research Network : Editors: Diego Muñoz Torrero, Amparo Cortés & Eduardo L. Mariño. ISBN: 978-81-7895-605-3. Chapter 5, p. 77-89. | - |
dc.relation.uri | http://hdl.handle.net/2445/46988 | - |
dc.rights | (c) Transworld Research Network, 2013 | - |
dc.source | Llibres / Capítols de llibre (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Investigació farmacèutica | cat |
dc.subject.classification | Obesitat | cat |
dc.subject.other | Pharmaceutical research | eng |
dc.subject.other | Obesity | eng |
dc.title | New strategies in the modulation of fatty acid oxidation as a treatment for obesity | eng |
dc.type | info:eu-repo/semantics/bookPart | eng |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 262667 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | eng |
Appears in Collections: | Llibres / Capítols de llibre (Bioquímica i Biomedicina Molecular) Llibres / Capítols de llibre (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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RAPS_III_Ch5.pdf | 2 MB | Adobe PDF | View/Open |
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