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Title: | Green tea catechin inhibits fatty acid synthase without stimulating carnitine Palmitoyltransferase-1 or inducing weight loss in experimental animals |
Author: | Puig i Miquel, Teresa Relat Pardo, Joana Marrero González, Pedro F. Haro Bautista, Diego Brunet, Joan Colomer Bosch, Ramón |
Keywords: | Àcids grassos Metabolisme Enzimologia Quimioteràpia del càncer Medicaments antineoplàstics Efectes secundaris dels medicaments Te Càncer de mama Aprimament Fatty acids Metabolism Enzymology Cancer chemotherapy Antineoplastic agents Drug side effects Tea Breast cancer Weight loss |
Issue Date: | Nov-2008 |
Publisher: | International Institute of Anticancer Research |
Abstract: | Background: The enzyme fatty acid synthase (FASN) is highly expressed in many human carcinomas and its inhibition is cytotoxic to human cancer cells. The use of FASN inhibitors has been limited until now by anorexia and weight loss, which is associated with the stimulation of fatty acid oxidation. Materials and Methods: The in vitro effect of (-)-epigallocatechin-3-gallate (EGCG) on fatty acid metabolism enzymes, on apoptosis and on cell signalling was evaluated. In vivo, the effect of EGCG on animal body weight was addressed. Results: EGCG inhibited FASN activity, induced apoptosis and caused a marked decrease of human epidermal growth factor receptor 2 (HER2), phosphatidylinositol 3-kinase (PI3K)/AKT and extracellular (signal)-regulated kinase (ERK) 1/2 proteins, in breast cancer cells. EGCG did not induce a stimulatory effect on CPT-1 activity in vitro (84% of control), or on animal body weight in vivo (99% of control). Conclusion: EGCG is a FASN inhibitor with anticancer activity which does not exhibit cross-activation of fatty acid oxidation and does not induce weight loss, suggesting its potential use as an anticancer drug. |
Note: | Reproducció del document publicat a: http://ar.iiarjournals.org/content/28/6A/3671.full.pdf+html |
It is part of: | Anticancer Research, 2008, vol. 28, num. 6A, p. 3671-3676 |
URI: | http://hdl.handle.net/2445/61729 |
ISSN: | 0250-7005 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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