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DC Field | Value | Language |
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dc.contributor.author | Vázquez Fresno, Rosa | - |
dc.contributor.author | Llorach, Rafael | - |
dc.contributor.author | Alcaro, Francesca | - |
dc.contributor.author | Rodríguez Martínez, Miguel Ángel | - |
dc.contributor.author | Vinaixa Crevillent, Maria | - |
dc.contributor.author | Chiva Blanch, Gemma | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | Correig Blanchar, Xavier | - |
dc.contributor.author | Andrés Lacueva, Ma. Cristina | - |
dc.date.accessioned | 2015-06-29T17:01:28Z | - |
dc.date.available | 2015-06-29T17:01:28Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0173-0835 | - |
dc.identifier.uri | http://hdl.handle.net/2445/66118 | - |
dc.description.abstract | Moderate wine consumption is associated with health-promoting activities. An H-NMR-based metabolomic approach was used to identify urinary metabolomic differences of moderate wine intake in the setting of a prospective, randomized, crossover, and controlled trial. Sixty-one male volunteers with high cardiovascular risk factors followed three dietary interventions (28 days): dealcoholized red wine (RWD) (272mL/day, polyphenol control), alcoholized red wine (RWA) (272mL/day) and gin (GIN) (100mL/day, alcohol control). After each period, 24-h urine samples were collected and analyzed by (1) H-NMR. According to the results of a one-way ANOVA, significant markers were grouped in four categories: alcohol-related markers (ethanol); gin-related markers; wine-related markers; and gut microbiota markers (hippurate and 4-hydroxphenylacetic acid). Wine metabolites were classified into two groups; first, metabolites of food metabolome: tartrate (RWA and RWD), ethanol, and mannitol (RWA); and second, biomarkers that relates to endogenous modifications after wine consumption, comprising branched-chain amino acid (BCAA) metabolite (3-methyl-oxovalerate). Additionally, a possible interaction between alcohol and gut-related biomarkers has been identified. To our knowledge, this is the first time that this approach has been applied in a nutritional intervention with red wine. The results show the capacity of this approach to obtain a comprehensive metabolome picture including food metabolome and endogenous biomarkers of moderate wine intake. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1002/elps.201100646 | - |
dc.relation.ispartof | Electrophoresis, 2012, vol. 33, num. 15, p. 2345-2354 | - |
dc.relation.uri | http://dx.doi.org/10.1002/elps.201100646 | - |
dc.rights | (c) Wiley-VCH, 2012 | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Vi | - |
dc.subject.classification | Consum d'alcohol | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.classification | Ressonància magnètica nuclear | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Metabòlits | - |
dc.subject.other | Wine | - |
dc.subject.other | Drinking of alcoholic beverages | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Cardiovascular diseases | - |
dc.subject.other | Nuclear magnetic resonance | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Metabolites | - |
dc.title | (1)H-NMR-based metabolomic analysis of the effect of moderate wine consumption on subjects with cardiovascular risk factors | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 618281 | - |
dc.date.updated | 2015-06-29T17:01:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
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618281.pdf | 713.82 kB | Adobe PDF | View/Open |
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