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DC Field | Value | Language |
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dc.contributor.author | Karachaliou, Marianna | - |
dc.contributor.author | Moncunill, Gemma | - |
dc.contributor.author | Espinosa, Ana | - |
dc.contributor.author | Castaño-Vinyals, Gemma | - |
dc.contributor.author | Jiménez, Alfons | - |
dc.contributor.author | Vidal, Marta | - |
dc.contributor.author | Santano, Rebeca | - |
dc.contributor.author | Barrios, Diana | - |
dc.contributor.author | Puyol, Laura | - |
dc.contributor.author | Carreras, Anna | - |
dc.contributor.author | Mayer, Leonie | - |
dc.contributor.author | Rubio, Rocío | - |
dc.contributor.author | Cortés, Beatriz | - |
dc.contributor.author | Pleguezuelos, Vanessa | - |
dc.contributor.author | O'Callaghan Gordo, Cristina | - |
dc.contributor.author | Fossati, Serena | - |
dc.contributor.author | Rivas, Ioar | - |
dc.contributor.author | Casabonne, Delphine | - |
dc.contributor.author | Vrijheid, Martine | - |
dc.contributor.author | Izquierdo, Luis | - |
dc.contributor.author | Aguilar, Ruth | - |
dc.contributor.author | Basagaña, Xavier | - |
dc.contributor.author | García Aymerich, Judith | - |
dc.contributor.author | Cid, Rafael de | - |
dc.contributor.author | Dobaño, Carlota, 1969- | - |
dc.contributor.author | Kogevinas, Manolis | - |
dc.date.accessioned | 2021-11-18T09:37:19Z | - |
dc.date.available | 2021-11-18T09:37:19Z | - |
dc.date.issued | 2021-11-03 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181352 | - |
dc.description.abstract | Sparse data exist on the complex natural immunity to SARS-CoV-2 at the population level. We applied a well-validated multiplex serology test in 5000 participants of a general population study in Catalonia in blood samples collected from end June to mid November 2020. Based on responses to fifteen isotype-antigen combinations, we detected a seroprevalence of 18.1% in adults (n = 4740), and modeled extrapolation to the general population of Catalonia indicated a 15.3% seroprevalence. Antibodies persisted up to 9 months after infection. Immune profiling of infected individuals revealed that with increasing severity of infection (asymptomatic, 1-3 symptoms, ≥ 4 symptoms, admitted to hospital/ICU), seroresponses were more robust and rich with a shift towards IgG over IgA and anti-spike over anti-nucleocapsid responses. Among seropositive participants, lower antibody levels were observed for those ≥ 60 years vs < 60 years old and smokers vs non-smokers. Overweight/obese participants vs normal weight had higher antibody levels. Adolescents (13-15 years old) (n = 260) showed a seroprevalence of 11.5%, were less likely to be tested seropositive compared to their parents and had dominant anti-spike rather than anti-nucleocapsid IgG responses. Our study provides an unbiased estimate of SARS-CoV-2 seroprevalence in Catalonia and new evidence on the durability and heterogeneity of post-infection immunity. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-00807-4 | - |
dc.relation.ispartof | Scientific Reports, 2021, vol. 11, num. 1 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-021-00807-4 | - |
dc.rights | cc-by (c) Karachaliou, Marianna et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Epidemiologia | - |
dc.subject.classification | Catalunya | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Epidemiology | - |
dc.subject.other | Catalonia | - |
dc.title | Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.type | info:eu-repo/semantics/article | - |
dc.date.updated | 2021-11-18T09:19:10Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/801370/EU//BP3 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34732749 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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s41598-021-00807-4.pdf | 2.19 MB | Adobe PDF | View/Open |
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