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DC Field | Value | Language |
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dc.contributor.author | Zhang, Qian | - |
dc.contributor.author | Pizzorno, Andrés | - |
dc.contributor.author | Miorin, Lisa | - |
dc.contributor.author | Bastard, Paul | - |
dc.contributor.author | Gervais, Adrian | - |
dc.contributor.author | Le Voyer, Tom | - |
dc.contributor.author | Bizien, Lucy | - |
dc.contributor.author | Manry, Jeremy | - |
dc.contributor.author | Rosain, Jérémie | - |
dc.contributor.author | Philippot, Quentin | - |
dc.contributor.author | Goavec, Kelian | - |
dc.contributor.author | Wroblewski, Isabelle | - |
dc.contributor.author | Husebye, Eystein | - |
dc.contributor.author | Fellay, Jacques | - |
dc.contributor.author | Pothier, Pierre | - |
dc.contributor.author | Morand, Patrice | - |
dc.contributor.author | Navarrete, Nicolás | - |
dc.contributor.author | Franco, José Luis | - |
dc.contributor.author | Uddin, Mohammed J. | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.contributor.author | Merino Díaz, Laura | - |
dc.contributor.author | Palomo, Virginia | - |
dc.contributor.author | Seppänen, Mikko R.J. | - |
dc.contributor.author | Särekannu, Karita | - |
dc.contributor.author | Aiuti, Alessandro | - |
dc.contributor.author | Retamar Gentil, Pilar | - |
dc.contributor.author | Debette, Stéphanie | - |
dc.contributor.author | Belot, Alexandre | - |
dc.contributor.author | Abel, Laurent | - |
dc.contributor.author | Soler Palacín, Pere | - |
dc.contributor.author | Abad Arranz, Maria | - |
dc.contributor.author | Aguilar Guisado, Manuela | - |
dc.contributor.author | Meyts, Isabelle | - |
dc.contributor.author | Casanova, Jean-Laurent | - |
dc.contributor.author | Gonzalez Granado, Luis L. | - |
dc.contributor.author | Butte, Manish J. | - |
dc.contributor.author | Itan, Yuval | - |
dc.contributor.author | Escoresca Ortega, Ana | - |
dc.contributor.author | Morio, Tomohiro | - |
dc.contributor.author | Padey, Blandine | - |
dc.contributor.author | Niubó, Jordi | - |
dc.contributor.author | Gallardo Ríos, Rafaela | - |
dc.contributor.author | Lau, Yu-lung | - |
dc.contributor.author | Triantafyllia, Vasiliki | - |
dc.contributor.author | Briones, Marisa | - |
dc.contributor.author | Saker, Kahina | - |
dc.contributor.author | Richard, Pascale | - |
dc.contributor.author | Drolet, Beth A. | - |
dc.contributor.author | Espinosa Padilla, Sara | - |
dc.contributor.author | Wauters, Joost | - |
dc.contributor.author | Peigue Lafeuille, Helene | - |
dc.contributor.author | Valiente, Adoración | - |
dc.contributor.author | El Baghdadi, Jamila | - |
dc.contributor.author | Tiberghien, Pierre | - |
dc.contributor.author | Balsera-manzanero, María | - |
dc.contributor.author | Zins, Marie | - |
dc.contributor.author | Hammarström, Lennart | - |
dc.contributor.author | Andreakos, Evangelos | - |
dc.contributor.author | Notarangelo, Luigi D. | - |
dc.contributor.author | Debette, Stéphanie | - |
dc.contributor.author | Prando, Carolina | - |
dc.contributor.author | Condino-neto, Antonio | - |
dc.contributor.author | Dominguez Pinilla, Nerea | - |
dc.contributor.author | Meyts, Isabelle | - |
dc.contributor.author | Aydillo, Teresa | - |
dc.contributor.author | Okamoto, Keisuke | - |
dc.contributor.author | Soumaré, Aïcha | - |
dc.contributor.author | Karamitros, Timokratis | - |
dc.contributor.author | Medina, Rafael A. | - |
dc.contributor.author | Kisand, Kai | - |
dc.contributor.author | Ramírez Duque, Nieves | - |
dc.contributor.author | Feys, Simon | - |
dc.contributor.author | Romero Oraa, Laura | - |
dc.contributor.author | Kuo, Chen-yen | - |
dc.contributor.author | Lei, Wei-te | - |
dc.contributor.author | Quintana Murci, Lluis | - |
dc.contributor.author | Milner, Joshua D. | - |
dc.contributor.author | Ku, Cheng-lung | - |
dc.contributor.author | Van De Beek, Diederik | - |
dc.contributor.author | Hsieh, Elena W.Y. | - |
dc.contributor.author | Tal, Galit | - |
dc.contributor.author | Fournet, Thomas | - |
dc.contributor.author | Cerba Healthcare Group | - |
dc.contributor.author | Patural, Hugues | - |
dc.contributor.author | Novelli, Giuseppe | - |
dc.contributor.author | Lyon Antigrippe Working Group | - |
dc.contributor.author | Arias, Andrés A. | - |
dc.contributor.author | Rovina, Nikoletta | - |
dc.contributor.author | Rodríguez-gallego, Carlos | - |
dc.contributor.author | Puel, Anne | - |
dc.contributor.author | Jouanguy, Emmanuelle | - |
dc.contributor.author | Vinh, Donald C. | - |
dc.contributor.author | Abel, Laurent | - |
dc.contributor.author | Henny, Joseph | - |
dc.contributor.author | Mogensen, Trine H. | - |
dc.contributor.author | Cobat, Aurélie | - |
dc.contributor.author | Casari, Giorgio | - |
dc.contributor.author | Ramaswamy, Sathishkumar | - |
dc.contributor.author | Abelenda Alonso, Gabriela | - |
dc.contributor.author | Morel, Pascal | - |
dc.contributor.author | Trouillet Assant, Sophie | - |
dc.contributor.author | Tzourio, Christophe | - |
dc.contributor.author | Gallian, Pierre | - |
dc.contributor.author | Reipi Inf Working Group | - |
dc.contributor.author | García Sastre, Adolfo | - |
dc.contributor.author | Constantinescu, Stefan N. | - |
dc.contributor.author | Hamzeh Cognasse, Hind | - |
dc.contributor.author | Haerynck, Filomeen | - |
dc.contributor.author | Flores, Carlos | - |
dc.contributor.author | Bousfiha, Ahmed A. | - |
dc.contributor.author | García Salum, Tamara | - |
dc.contributor.author | Shahrooei, Mohammed | - |
dc.contributor.author | Slaby, Ondrej | - |
dc.contributor.author | Fragkou, Paraskevi C. | - |
dc.contributor.author | Argaud, Laurent | - |
dc.contributor.author | Belot, Alexandre | - |
dc.contributor.author | Shcherbina, Anna | - |
dc.contributor.author | Al-muhsen, Saleh | - |
dc.contributor.author | Biggs, Catherine M. | - |
dc.contributor.author | Bogunovic, Dusan | - |
dc.contributor.author | Planas, Anna M. | - |
dc.contributor.author | Heath, James R. | - |
dc.contributor.author | Von Bernuth, Horst | - |
dc.contributor.author | Dufouil, Carole | - |
dc.contributor.author | Bolze, Alexandre | - |
dc.contributor.author | Boeuf, Benoit | - |
dc.contributor.author | Rodríguez Gallego, Carlos | - |
dc.contributor.author | Christodoulou, John | - |
dc.contributor.author | Bondarenko, Anastasiia | - |
dc.contributor.author | Martin, Fernando | - |
dc.contributor.author | Koltsida, Ourania | - |
dc.contributor.author | Sediva, Anna | - |
dc.contributor.author | Ruiz Hernandez, José Juan | - |
dc.contributor.author | Bonneaudeau, Brigitte | - |
dc.contributor.author | Cannet, Dorothée | - |
dc.contributor.author | Ku, Cheng-lung | - |
dc.contributor.author | Etablissement Français Du Sang Study Group | - |
dc.contributor.author | Froidure, Antoine | - |
dc.contributor.author | Laurent, Emilie | - |
dc.contributor.author | Galani, Ioanna Evdokia | - |
dc.contributor.author | Gregersen, Peter K. | - |
dc.contributor.author | Lemonnier, Sylvie | - |
dc.contributor.author | Spaan, András N. | - |
dc.contributor.author | Darmon, Michael | - |
dc.contributor.author | Grimbacher, Bodo | - |
dc.contributor.author | Del Mar Muñoz Garcia, Maria | - |
dc.contributor.author | Zawadzki, Pawel | - |
dc.contributor.author | Henrickson, Sarah E. | - |
dc.contributor.author | Haerynck, Filomeen | - |
dc.contributor.author | O'farrelly, Cliona | - |
dc.contributor.author | Rosa Calatrava, Manuel | - |
dc.contributor.author | Lachaize, Morgane | - |
dc.contributor.author | Okada, Satoshi | - |
dc.contributor.author | Vanker, Martti | - |
dc.contributor.author | Bryceson, Yenan | - |
dc.contributor.author | Ling, Yun | - |
dc.contributor.author | Cooper, Megan A. | - |
dc.contributor.author | Lucas, Carrie L. | - |
dc.contributor.author | Maniatis, Tom | - |
dc.contributor.author | Romero Vázquez, Gloria María | - |
dc.contributor.author | Mansouri, Davood | - |
dc.contributor.author | Castagnoli, Riccardo | - |
dc.contributor.author | Zins, Marie | - |
dc.contributor.author | Maródi, László | - |
dc.contributor.author | Mironska, Kristina | - |
dc.contributor.author | Rapti, Vasiliki | - |
dc.contributor.author | Baris Feldman, Hagit | - |
dc.contributor.author | Pozzetto, Bruno | - |
dc.contributor.author | Renia, Laurent | - |
dc.contributor.author | Tancevski, Ivan | - |
dc.contributor.author | Imai, Kohsuke | - |
dc.contributor.author | Ozcelik, Tayfun | - |
dc.contributor.author | Pan-hammarström, Qiang | - |
dc.contributor.author | Al-mulla, Fahd | - |
dc.contributor.author | Pape, Jean W. | - |
dc.contributor.author | Etzioni, Amos | - |
dc.contributor.author | Souweine, Bertrand | - |
dc.contributor.author | Perez De Diego, Rebeca | - |
dc.contributor.author | Wauters, Joost | - |
dc.contributor.author | Sánchez Cordero, Maria Jose | - |
dc.contributor.author | Solé Violán, Jordi | - |
dc.contributor.author | Perlin, David S. | - |
dc.contributor.author | Queromes, Gregory | - |
dc.contributor.author | Anderson, Mark S. | - |
dc.contributor.author | Resnick, Igor | - |
dc.contributor.author | Pesole, Graziano | - |
dc.contributor.author | Su, Helen C. | - |
dc.contributor.author | Vanderbeke, Lore | - |
dc.contributor.author | Hagin, David | - |
dc.contributor.author | Jeanne, Michel | - |
dc.contributor.author | Desai, Murkesh | - |
dc.contributor.author | Ferres, Marcela | - |
dc.contributor.author | Sánchez Céspedes, Javier | - |
dc.contributor.author | Perroquin, Magali | - |
dc.contributor.author | Ng, Lisa F.P. | - |
dc.contributor.author | Abou Tayoun, Ahmad | - |
dc.contributor.author | Le Corre, Nicole | - |
dc.contributor.author | Snow, Andrew L. | - |
dc.contributor.author | Temel, Şehime Gülsün | - |
dc.contributor.author | Tsiodras, Sotirios | - |
dc.contributor.author | Coeuret Pellicer, Mireille | - |
dc.contributor.author | Notarangelo, Luigi D. | - |
dc.contributor.author | Javouhey, Etienne | - |
dc.contributor.author | Turvey, Stuart E. | - |
dc.contributor.author | Covid Human Genetic Effort | - |
dc.contributor.author | Rombauts, Alexander | - |
dc.contributor.author | Zatz, Mayana | - |
dc.contributor.author | Uddin, K.m. Furkan | - |
dc.contributor.author | Kisand, Kai | - |
dc.contributor.author | Fievet, Nathalie | - |
dc.contributor.author | Jarvis, Erich D. | - |
dc.contributor.author | Rodríguez De Castro, Felipe | - |
dc.contributor.author | Ferreres, José | - |
dc.contributor.author | Flaig, Amandine | - |
dc.contributor.author | Pujol, Aurora | - |
dc.contributor.author | Cognasse, Fabrice | - |
dc.contributor.author | Sancho Shimizu, Vanessa | - |
dc.contributor.author | Tiberghien, Pierre | - |
dc.contributor.author | Nadif, Rachel | - |
dc.contributor.author | Hanna, Suhair | - |
dc.contributor.author | Constances Cohort | - |
dc.contributor.author | Goldberg, Marcel | - |
dc.contributor.author | Brodin, Petter | - |
dc.contributor.author | Andreakos, Evangelos | - |
dc.contributor.author | Le Got, Stéphane | - |
dc.contributor.author | Ozguler, Anna | - |
dc.contributor.author | Quenot, Jean Pierre | - |
dc.contributor.author | Novelli, Antonio | - |
dc.contributor.author | Cordero, Elisa | - |
dc.contributor.author | Colomb, Benoit | - |
dc.contributor.author | Cupic, Anastasija | - |
dc.contributor.author | Mehlal Sedkaoui, Souad | - |
dc.contributor.author | Sallette, Jérôme | - |
dc.contributor.author | Hernu, Romain | - |
dc.contributor.author | Bustamante, Carlos D. | - |
dc.contributor.author | Lina, Bruno | - |
dc.contributor.author | Halwani, Rabih | - |
dc.contributor.author | Casalegno, Jean Sebastien | - |
dc.contributor.author | Schwebel, Carole | - |
dc.contributor.author | Salamanca Rivera, Celia | - |
dc.contributor.author | 3C-Dijon Study | - |
dc.contributor.author | Tangye, Stuart G. | - |
dc.contributor.author | Dalgard, Clifton L. | - |
dc.date.accessioned | 2022-12-23T08:35:25Z | - |
dc.date.available | 2022-12-23T08:35:25Z | - |
dc.date.issued | 2022-09-16 | - |
dc.identifier.issn | 1540-9538 | - |
dc.identifier.uri | http://hdl.handle.net/2445/191806 | - |
dc.description.abstract | In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine. Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-alpha 2 alone (five patients) or with IFN-omega (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-alpha 2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-omega. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients <70 yr of age (5.7 vs. 1.1%, P = 2.2 x 10(-5)), but not >70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-alpha 2 and IFN-omega (OR = 11.7, P = 1.3 x 10(-5)), especially those <70 yr old (OR = 139.9, P = 3.1 x 10(-10)). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for similar to 5% of cases of life-threatening influenza pneumonia in patients <70 yr old. | - |
dc.format.extent | 29 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Rockefeller University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1084/jem.20220514 | - |
dc.relation.ispartof | Journal of Experimental Medicine, 2022, vol. 219, issue. 11 | - |
dc.relation.uri | https://doi.org/10.1084/jem.20220514 | - |
dc.rights | cc by (c) Zhang, Qian et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Grip | - |
dc.subject.classification | Pneumònia | - |
dc.subject.classification | Autoanticossos | - |
dc.subject.other | Influenza | - |
dc.subject.other | Pneumonia | - |
dc.subject.other | Autoantibodies | - |
dc.title | Autoantibodies against type I IFNs in patients with critical influenza pneumonia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-12-20T10:06:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36112363 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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jem_20220514.pdf | 3.28 MB | Adobe PDF | View/Open |
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