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https://dipositint.ub.edu/dspace/handle/2445/192884
Title: | Cellular senescence is immunogenic and promotes anti-tumor immunity |
Author: | Marin, Ines Boix, Olga Garcia Garijo, Andrea Sirois, Isabelle Caballe, Adrià Zarzuela, Eduardo Ruano, Irene Stephan-Otto Attolini, Camille Prats, Neus López Domínguez, José A. Kovatchev, Marta Garralda, Elena Muñoz, Javier Caron, Etinne Abad, María Gros, Alena Pietrocola, Federico Serrano, Manuel |
Keywords: | Cèl·lules canceroses Immunitat cel·lular Cancer cells Cellular immunity |
Issue Date: | 31-Jul-2022 |
Publisher: | American Association for Cancer Research |
Abstract: | Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of interferon signaling, enhanced MHC class I machinery, and presentation of senescence-specific self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong anti-tumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells undergoing immunogenic cell death. Finally, the induction of senescence in human primary cancer cells also augments their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. Our study indicates that senescent cancer cells can be exploited to develop efficient and protective CD8-dependent anti-tumor immune responses. |
Note: | Reproducció del document publicat a: https://doi.org/10.1158/2159-8290.CD-22-0523 |
It is part of: | Cancer Discovery, 2023, vol. 13, num. 2, p. 410-431 |
URI: | http://hdl.handle.net/2445/192884 |
Related resource: | https://doi.org/10.1158/2159-8290.CD-22-0523 |
ISSN: | 2159-8290 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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Marin_Cancer Discovery_2023.pdf | 16.78 MB | Adobe PDF | View/Open |
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