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Issue Date	Title	Author(s)
17-Nov-2023	Targeted protein degradation: Proximity-inducing pharmacology	Winter GE; Mayor-Ruiz C
28-Aug-2023	Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase	de Potter B; Vallee I; Camacho N; Filipe Costa Póvoas L; Bonsembiante A; Pons I Pons A; Eckhard U; Gomis-Rüth FX; Yang XL; Schimmel P; Kuhle B; Ribas de Pouplana L
28-Dec-2023	Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.	Barbosa, Bárbara M. G.; Sfyaki, Aikaterini; Rafael, Sergi; José-Duran, Ferran; Pous, Joan; Sánchez Zarzalejo, Carolina; Perez-Lopez, Carles; Vilanova, Mar; Cigler, Marko; Gay, Marina; Vilaseca, Marta; Winter, Georg E.; Riera i Escalé, Antoni; Mayor-Ruiz, Cristina
Mar-2024	Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD	Bórquez, Juan Carlos; Díaz-Castro, Francisco; Pino-de La Fuente, Francisco; Espinoza, Karla; Figueroa, Ana María; Martínez-Ruiz, Inma; Hernández, Vanessa; López-Soldado, Iiana; Ventura, Raúl; Domingo i Pedrol, Joan Carles; Bosch i Rodríguez, Marta; Fajardo, Alba; Sebastián Muñoz, David; Espinosa, Alejandra; Pol i Sorolla, Albert; Zorzano Olarte, Antonio; Cortés, Víctor; Hernández-Alvarez, María Isabel; Troncoso, Rodrigo
5-Feb-2020	Pathway and network analysis of more than 2500 whole cancer genomes	Reyna, Matthew A.; Haan, David; Paczkowska, Marta; Verbeke, Lieven P. C.; Vazquez, Miguel; Kahraman, Abdullah; Pulido-Tamayo, Sergio; Barenboim, Jonathan; Wadi, Lina; Dhingra, Priyanka; Shrestha, Raunak; Getz, Gad; Lawrence, Michael S.; Pedersen, Jakob Skou; Rubin, Mark A.; Wheeler, David A.; Brunak, Søren; Izarzugaza, Jose M. G.; Khurana, Ekta; Marchal, Kathleen; von Mering, Christian; Sahinalp, S. Cenk; Valencia, Alfonso; PCAWG Drivers and Functional Interpretation Working Group; Reimand, Jüri; Stuart, Joshua M.; Raphael, Benjamin J.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
5-Feb-2020	Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig	Rubanova, Yulia; Shi, Ruian; Harrigan, Caitlin F.; Li, Roujia; Wintersinger, Jeff; Sahin, Nil; Deshwar, Amit G.; PCAWG Evolution and Heterogeneity Working Group; Morris, Quaid D.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
5-Feb-2020	A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns	Jiao, Wei; Atwal, Gurnit; Polak, Paz; Karlic, Rosa; Cuppen, Edwin; PCAWG Tumor Subtypes and Clinical Translation Working Group; Danyi, Alexandra; de Ridder, Jeroen; van Herpen, Carla; Lolkema, Martijn P.; Steeghs, Neeltje; Getz, Gat; Morris, Quaid D.; Stein, Lincoln D.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
15-Jul-2023	EvolClustDB: Exploring Eukaryotic Gene Clusters with Evolutionarily Conserved Genomic Neighbourhoods	Marcet-Houben M; Collado-Cala I; Fuentes-Palacios D; Gómez AD; Molina M; Garisoain-Zafra A; Chorostecki U; Gabaldon T
5-Feb-2020	Combined burden and functional impact tests for cancer driver discovery using DriverPower	Shuai, Shimin; PCAWG Drivers and Functional Interpretation Working Group; Gallinger, Steven; Stein, Lincoln D.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
7-Dec-2021	Structural basis for substrate specificity of heteromeric transporters of neutral amino acids	Rodriguez, Carlos F.; Escudero-Bravo, Paloma; Díaz, Lucía; Bartoccioni, Paola; Martín García, Carmen; Gilabert, Joan G.; Boskovic, Jasminka; Guallar i Tasies, Víctor; Errasti-Murugarren, Ekaitz; Llorca, Oscar; Palacín Prieto, Manuel
15-Mar-2023	Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	Fernandez Alfara, M.; Sibilio, A.; Martin, J.; Uxo, E. T.; Malumbres, M.; Alcalde, V.; Chanes, V.; Canellas Socias, A.; Palomo Ponce, S.; Batlle, Eduard; Mendez, R.
1-Jan-2022	Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype	Maus, Mate; Serrano Marugán, Manuel; Lopez Polo, Vanessa; Mateo Ramos, Lidia; Aguilera Pujabet, Monica; Meyer, Kathleen; Hernández González, Fernanda Inés; Oliveira Monteiro, Freddy Miguel de; Stephan-Otto Attolini, Camille; Prats Costa, Neus; Cruzado, Josep Ma.; Albaiceta, Guillermo M.; Engelhardt, Stefan; Manonelles, Anna; Ortega, Sagrario; Diéguez Hurtado, Rodrigo; Agustí García-Navarro, Àlvar; Faner, Rosa; Sánchez, Mayka; Rovira, Miguel; Chaib, Selim; Guasch Piqueras, Marc; López Alonso, Inés; López Martínez, Cecilia; Sola Martínez, Anna; Lama, Eugenia de; Lafarga, Miguel
18-Jan-2023	Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α	Cubillos Rojas, Mónica; Loren, Guillem; Hakim, Yusuf Z.; Verdaguer i Espaulella, Xavier; Riera i Escalé, Antoni; Nebreda, Àngel R.
1-Jan-2023	Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α	Pous, Joan; Bagiński, Błażej Mikołaj; Martín Malpartida, Pau; González, Lorena; Scarpa, Margherita; Aragón Altarriba, Eric; Ruiz, Lidia; Mees, Rebeca A.; Iglesias Fernández, Javier; Orozco López, Modesto; Nebreda, Àngel R.; Macias, Maria Jesus
16-Nov-2023	Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair	Kovatcheva, Marta; Meléndez Esteban, Elena; Chondronasiou, Dafni; Pietrocola, Federico; Bernad, Raquel; Caballé Mestres, Adrià; Junza Martínez, Alexandra; Capellades, Jordi; Holguín Horcajo, Adrián; Prats, Neus; Durand, Sylvere; Rovira, Meritxell; Yanes, Oscar; Stephan-Otto Attolini, Camille; Kroemer, Guido; Serrano Marugán, Manuel
27-Apr-2023	BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M	Gallisà Suñé, Núria; Sànchez Fernàndez de Landa, Paula; Zimmermann, Fabian; Serna, Marina; Regué, Laura; Paz Domínguez, Joel; Llorca, Oscar; Luders, Jens; Roig Amorós, Joan
1-Jan-2023	The TNFR Wengen regulates the FGF pathway by an unconventional mechanism	Letizia, Annalisa; Espinás, Maria Lluïsa; Giannios, Panagiotis; Llimargas i Casanova, Marta
10-Sep-2023	Higher circulating Vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice	Domínguez López, Inés; Kovatcheva, Marta; Casas, Rosa; Toledo, Estefanía; Fitó, Montserrat; Ros, Emilio; Estruch, Ramon; Serrano, Manuel; Lamuela Raventós, Rosa M.
29-Apr-2023	Positive feedback induces switch between distributive and processive phosphorylation of Hog1	Mosbacher, Maximilian; Lee, Sung Sik; Yaakov, Gilad; Nadal Ribelles, Mariona; Nadal , Eulàlia de; van Drogen, Frank; Posas, Francesc; Peter, Matthias; Claassen, Manfred
25-Aug-2022	Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis	Sabaté Pérez, Alba; Romero, Montserrat; Sànchez Fernàndez de Landa, Paula; Carobbio, Stefania; Mouratidis, Michail; Sala Cano, David; Engel Rocamora, Pablo; Villena, Josep A.; Virtue, Sam; Vidal Puig, Antonio; Palacín Prieto, Manuel; Testar, Xavier; Zorzano Olarte, Antonio

Recent Submissions

Targeted protein degradation: Proximity-inducing pharmacology

Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.

Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD

Pathway and network analysis of more than 2500 whole cancer genomes