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https://dipositint.ub.edu/dspace/handle/2445/202167| Title: | Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes |
| Author: | Tarifa, Carmen Vallmitjana, Alexander Jiménez Sábado, Verónica Marchena, Miquel Llach, Anna Herraiz Martínez, Adela Godoy-Marín, Héctor Nolla-Colomer, Carme Ginel, Antonino Viñolas, Xavier Montiel, José Ciruela Alférez, Francisco Echebarria, Blas Benitez, Raúl Cinca, Juan Hove-Madsen, Leif |
| Keywords: | Fibril·lació auricular Cèl·lules musculars Canals de calci Atrial fibrillation Muscle cells Calcium channels |
| Issue Date: | 1-Feb-2023 |
| Publisher: | Elsevier B.V. |
| Abstract: | Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF |
| Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jacbts.2022.07.013 |
| It is part of: | JACC: Basic to Translational Science, 2023, vol. 8, num. 1, p. 1-15 |
| URI: | https://hdl.handle.net/2445/202167 |
| Related resource: | https://doi.org/10.1016/j.jacbts.2022.07.013 |
| ISSN: | 2452-302X |
| Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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| 732318.pdf | 3.41 MB | Adobe PDF | View/Open |
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